Aim: Parental childhood traumas significantly influence their parenting styles. This study examines the relationship between childhood neglect and abuse experienced by Generation Y parents and their parental attitudes. Materials and Method: A total of 106 participants (60 women, 46 men) aged 25–40 years completed the Sociodemographic Information Form, Parental Attitude Scale (PAS), and Childhood Trauma Questionnaire (CTQ). Data collection was conducted online following ethical approval. Statistical analyses were performed using SPSS 24.0. Results: Emotional abuse and neglect were positively correlated with authoritarian and permissive parental attitudes. Conversely, a negative correlation was observed between emotional neglect and democratic attitudes. Income level, marital status, and self-harm history significantly influenced CTQ and PAS scores, with authoritarian attitudes being higher in women and younger parents. Conclusions: Childhood traumas are intergenerational and extend beyond individual experiences, influencing societal structures. Addressing trauma requires holistic community interventions. Future studies should expand on how unresolved parental traumas shape generational outcomes.

Aim: Resting-state gamma oscillations, less studied compared to task-related gamma activity, have increasingly been considered to reflect baseline cognitive processes and readiness for future cognitive demands. Previous research has largely focused on clinical populations, identifying aberrant gamma activity as a marker of cognitive dysfunction in conditions such as schizophrenia, Alzheimer’s disease, and ADHD. This study investigates the relationship between resting-state EEG gamma power and neuropsychological performance in healthy adults. Specifically, it examines the associations between absolute and relative gamma power across different brain regions (frontal, temporal, parietal, and occipital) during resting-state and performance in cognitive domains such as working memory, verbal fluency, face recognition, short-term memory, and attention. Material and Methods: A total of 45 healthy individuals who underwent routine neuropsychiatric evaluations at NP Istanbul Brain Hospital and exhibited no pathological findings were included in the study. Resting-state EEG data, collected retrospectively, were analyzed to extract gamma power values, which were subsequently correlated with neuropsychological test scores. Results: The results revealed significant positive correlations between relative gamma power in the frontal and parietal regions and verbal fluency performance. This association suggests that specific brain regions contribute uniquely to cognitive functions during resting states, with gamma power providing insight into the neural substrates of language-related abilities. Conclusion: These findings highlight the relevance of resting-state gamma power in understanding individual differences in cognitive abilities. Future research should validate these findings with larger, more diverse samples and incorporate advanced techniques like MEG to better understand the neural mechanisms linking gamma oscillations to cognitive performance.

Body Dysmorphic Disorder (BDD) is characterized by obsessive preoccupation with perceived physical
flaws, often unnoticed by others. This preoccupation causes significant emotional distress, social withdrawal,
and functional impairment. Recent advancements emphasize the importance of integrating neurobiological
and behavioral perspectives in understanding BDD. This review synthesizes findings from
neuroscience and behavioral psychology to examine the brain-behavior relationship in BDD and explores
implications for treatment strategies. A narrative synthesis of current literature, including neuroimaging,
neurochemical studies, and behavioral research, was conducted. Evidence from clinical trials on pharmacological
treatments, cognitive-behavioral therapy, and neuromodulation techniques was analyzed.
Neuroimaging studies reveal hyperactivity in the orbitofrontal cortex, amygdala, and fusiform gyrus, contributing
to obsessive thoughts, heightened emotional responses, and distorted visual processing. Neurochemical
imbalances, particularly in serotonin, dopamine, and gamma-aminobutyric acid systems, perpetuate
cognitive distortions and compulsive behaviors. Cognitive patterns, including selective attention to
perceived flaws, catastrophic thinking, and overestimation of others’ judgments, interact with maladaptive
behaviors such as mirror checking, avoidance, and reassurance-seeking. Integrated treatments, including
selective serotonin reuptake inhibitors, cognitive-behavioral therapy, and transcranial magnetic stimulation,
address these interconnected mechanisms effectively. BDD arises from a complex interaction between
neurobiological dysfunction, cognitive distortions, and maladaptive behaviors. Effective treatment
requires a multidisciplinary approach targeting these domains. Future research should focus on longitudinal
brain plasticity studies, sex differences, and optimized neuromodulation protocols to enhance therapeutic
outcomes and personalized interventions.

Dear Editor, Nightmare disorder is a mental health condition characterized by repeated occurrences of extended, well-remembered, dysphoric dreams, often involving themes of threat, that result in awakening from sleep and significant distress and impairment1 . A typical sleep occurs in two phases namely rapid eye movement stage (REM) and nonrapid eye movement stage (NREM), nightmares usually occur during REM stage of sleep cycle when brain activity nears the level of that when an individual is awake causing the experience to feel real. Research points to factors such as traumatic experiences, childhood adversities, suppression of thoughts, maladaptive beliefs, other medical conditions such as sleep apnea2. Though research points to multiple reasons for occurrence of nightmares, Spoormaker’s cognitive model explains persistence of nightmares due to formation of nightmare scripts, the repeated elements in nightmares form structures patterns in dreamers experience. The scripts contain specific expected responses that get activated to dream elements, the cycle continues even after the original stressor fades

Dear Editor,
Infertility in women is defined as the inability
to conceive after a year of regular, unprotected
sexual activity 1 .While technological advancements
offer various medical interventions for
treatment, infertility can stem from issues with
ovulation, the uterus, fallopian tubes, or abdominal
factors. Sometimes, the cause remains
elusive despite thorough testing. However, infertility
isn’t solely a biological issue; adverse
childhood experiences (ACE) also play a role.
ACE encompass stressful or traumatic events
during the first 18 years of life, such as domestic
violence, substance abuse, parental mental
illness, divorce, or incarceration, which can impact
fertility beyond mere physiological factors.

The aim of this case report is to highlight the varied presentation of neurological disorders and the need
for detailed evalution of the acute manisfestations of psychiatric symptoms. We report the case of a 17 year
old boy presenting with complaints of acute onset of behavioural symptoms. We have briefly reviewed and
discussed the clinical , diagnostic aspects of schmahmanns syndrome and therapeutic aspects of behavioural
symptoms in dandy walkers malformation.

Aim: The study's long-term goals, such as determining supratherapeutic ranges according to age distributions
specific to the country, adjusting dosages for additional drugs used by patients in different disease
groups, and providing the opportunity for etiological studies in the light of diagnosis and drug metabolism
perspective, are of great importance in defining the study. Method: Population pharmacokinetics is a
method expressed to evaluate processes such as absorption, distribution, metabolism, and elimination of a
drug from an individual's blood-plasma concentration. In drug pharmacokinetic experiments, generating
data without considering any pharmacokinetic differences among patients prevents the measurement or
observation of variability among individuals in the population as a simple approach. The dose-concentration
relationship is crucial for individualized dose adjustment. Additionally, the impact of other drugs used
by the individual on metabolite levels and the metabolic interactions between drugs play a critical role in
the development of personalized treatments. Population approaches provide a foundation that benefits the
observation of these effects. The variability in drug metabolism among individuals forms one of the fundamental
building blocks of personalized treatment approaches, specifically through Therapeutic Drug Monitoring
(TDM), which plays an important role in determining the therapeutic range of drugs. Materials:
In this study, drug metabolism findings of patients served at NP Istanbul Brain Hospital between 2010 and
2022 were examined within the repository created along with other patient-specific parameters. Results
and Conclusion: The analysis results have been followed up longitudinally, partially demographically,
and retrospectively. Thanks to the repository of NP Istanbul Brain Hospital, population pharmacokinetic
analyses aimed in this study are being conducted for the first time globally and nationally in terms of
scope. The repository has been studied with TDM for individualized treatment methods, and within this
project, it is anticipated to perform phenotyping with the population pharmacokinetic approach.

Background: Lead acetate (Pb) exposure during frontal cortex development is associated with developmental
toxicity later in life, causing both morphological and functional alterations. Curcuma longa,
however, has been suggested to possess neuroprotective qualities that could lessen these adverse effects.
Objective: Assessed the frontal cortex following treatment with Curcuma longa. Materials and Methods:
Twenty adult female Wistar rats and ten adult male Wistar rats were matched during the proestrous phase
of the estrous cycle in order to mate and create five groups of six (n=6) in a 4:2 (4 females to 2 males)
ratio. Gestational day 0 was marked as the confirmation of pregnancy based on if sperm is present and a
vaginal plug in the vaginal smear. Four (n=4) pregnant Wistar rats were put together. Group 1 (control) rats
were given 2 milliliters per kilogram of distilled water. Pb was given at a dose of 120 mg/kg to Group 2.
Group 3 rats were given 120 mg/kg of lead and 100 mg/kg of vitamin C. The animals in Group 4 received
750 mg/kg of Curcuma longa and 120 mg/kg of Pb. The animals in Group 5 rats were given 1500 mg/kg
of Curcuma longa and 120 mg/kg of Pb. From gestational day 7 to day 21 (14 days), the medication was
administered orally. The animals were allowed to litter naturally. At postnatal day (PND) 1, some pups
were euthanized using chloroform inhalation and their brains were harvested for Oxidative stress markers,
histology, histochemical assessments. While some pups were kept for Cliff avoidance test at PND 4-7.
Results: The study found that lead acetate (Pb) exposure during gestation significantly decreased the mean
turning latency in the cliff avoidance test and increased lipid peroxidation (MDA) levels, while decreasing
antioxidant enzyme levels (SOD, CAT, GSH) compared to the control group. These neurological and oxidative
changes were mitigated by co-administration of Curcuma longa, with a notable improvement in the
cliff avoidance test performance and restoration of the altered histological and histochemical markers. The
results suggest that Curcuma longa, a natural antioxidant, has neuroprotective properties that can counteract
the adverse effects of lead toxicity during gestational development. Conclusion: N-Butanol Fraction
of Curcuma Longa ameliorated lead-induced neurotoxicity in rat pups.

Background: Benzodiazepines (BZDs) are a class of depressant drugs that have enjoyed widespread use
in conventional clinical management of anxiety-related conditions such as panic disorders that require
therapeutic central relaxation and sedation. Meanwhile, prolonged administration of benzodiazepines even
at low doses has however been linked to variety of undesirable effects such as discontinuation relapse with
the associated risk of abuse and dependency. Aim: This study investigated the behavioral, histological
and biochemical outcomes of long-term low dose diazepam use and explored the potential role of nigella
sativa oil (NSO) in the amelioration of the associated side effects. Methods: Adult Wistar rats (n=32)
were randomized into four groups that received normal saline; diazepam; diazepam + NSO; or NSO only,
respectively for 14 days. At the end of the period of the various exposures, the rats were taken through
behavioral paradigms after which they were sacrificed for chemical and histological profiling. Results:
diazepam-exposed rats exhibited stress-related manifestations with relatively poor performance in memory-
related tasks. Repeated diazepam ingestion reduced brain antioxidant biomarkers while causing elevation
of brain oxidative stress markers. On histological observation, mild degenerative changes were evident
in the various brain regions of the diazepam-exposed rats. Conclusion: Interventional nigella sativa oil
administration showed therapeutic potentials by mitigating and reversing the observed effects of diazepam,
largely due to its antioxidant and anti-inflammatory effects as observed in the present study.

Background: Pyrethroids pose health risks to humans. Therefore, it is imperative to assess the preventive
benefits of thymoquinone against neurotoxicity induced by cypermethrin- in the hippocampal dentate
gyrus. Methods: Forty male adult Wistar rats with an average weight of 180-200g were randomly allocated
to five (5) groups, and each comprising eight rats (n=8 per group). The groups were designated
as follows, through oral administrations for 14 days: 0.5ml phosphate- buffered saline (PBS) was given
to group one; Group two received 20mg/kg of cypermethrin (CYM); Group three received 10 mg/kg of
thymoquinone (THQ); Group four received 20 mg/kg of cypermethrin followed by 10mg/kg of thymoquinone
(CYM-10mgTHQ); and Group five received 20 mg/kg and 5mg/kg cypermethrin and thymoquinone
respectively (CYM-5 mgTHQ). Behavioral, histological, immunohistochemical, and biochemical analyses
were conducted post-treatment. Results: Cypermethrin administration caused the rise in pro-inflammatory
cytokine TNF-α, Nuclear Factor-kappa B (NF-κB) and increased expression of astrocytes, microglia, and
pro-apoptotic protein Bax. Additionally, cypermethrin reduced levels of anti-inflammatory cytokine IL-10
and acetylcholinesterase (AChE) activity. Cytoarchitectural disruption of dentate gyrus were observed.
Cognitive deficits were evident. Thymoquinone treatment attenuated TNF-α and NF-κB elevation, reduced
astrocyte, microglial, and Bax expression, and increased IL-10 and AChE. Conclusion: Thymoquinone
demonstrated anti-inflammatory and anti-apoptotic effects against cypermethrin-induced neurotoxicity,
improving cognitive function in rats.