JNBS
Üsküdar Üniversitesi

ARTICLES

Editorial

Turkish Title : The Pervasiveness of Autism Spectrum Disorder and the Calibrated Interventions

Wilson Jemima,Srikanth Pallerla
JNBS, 2023, 10(3), p:65-67

DOI : 10.4103/jnbs.jnbs_12_23

Autism spectrum disorder (ASD) is an umbrella term
comprising a group of neurological conditions marked by
severe difficulties with social interaction and communication.
According to the World Health Organization,[1] in 100
children worldwide suffer from ASD, and 1 in 500 Indian
children receive an autistic diagnosis. With four men
diagnosed for every female, boys are more likely than
females to be impacted by autism. Compared to Down
syndrome, which affects one in 800 newborns, autism occurs
more often. Children may exhibit a spectrum of symptoms,
varying in intensity, from recurring patterns of limited
interests and unusual behaviors to challenges in transitioning
between activities or events, as well as unexpected reactions
to sensory cues in their surroundings. While a cure for
autism is not currently evident, interventions play a crucial
role in assisting children to effectively manage their
symptoms. By tailoring treatment plans to individual needs,
these interventions contribute to an improved quality of life.


Review Article

Turkish Title : The Neurological and Psychological Effects of Breastfeeding on Women

Tapırdamaz Şeyda Nur,Esencan Tuğba Yılmaz
JNBS, 2023, 10(3), p:68-73

DOI : 10.4103/jnbs.jnbs_7_23

Breastfeeding is the key element of infant feeding and has played a vital role in promoting infant
health throughout history. It provides all the necessary nutrients for infants to grow and develop.
The World Health Organization (WHO) recommends initiating breastfeeding right after birth and
continuing with exclusive breastfeeding for the first 6 months, followed by complementary feeding
up to 24 months of age. The WHO has also set targets to increase exclusive breastfeeding rates by
2025. As scientific research has advanced, the benefits of breastfeeding for infant health have become
increasingly apparent, not only for metabolic diseases but also for cognitive health. As a result,
researchers have started examining whether breastfeeding has any neurological or psychological
effects on lactating mothers. In this review, we examined current research on the neurological and
psychological effects of breastfeeding on women.


Original Article

Turkish Title : Neuromorphological and Biochemical Effects of Co-exposure to Bisphenol A and Cadmium in Insulin-resistant Rats

Lawal Abdulwasiu Taiwo,Sharafadeen Ahmed Olamilekan,Akinola Oluwole Busayo
JNBS, 2023, 10(3), p:74-81

DOI : 10.4103/jnbs.jnbs_14_23

Background: Cadmium (Cd) and bisphenol A (BPA) are known industrial additives and
environmental toxicants that have been extensively reported for their various deleterious effects
on biological systems, particularly endocrine disruption and neurotoxicity. In high‑fat diet‑induced
insulin‑resistant model rats, we studied the neurotoxicity and oxidative stress effects of co‑exposure to
Cd and BPA. Aims: This study aims to look at prefrontal microarchitecture and antioxidant profiles in
insulin‑resistant rats. Materials and Methods: Twenty‑five adult Wistar rats were randomly assigned
into five groups (A– E; n = 5). With A receiving normal saline; B: 40 mg/kg. bw CdCl2 + high‑fat
diet (HFD) + Suc; C: 40 mg/kg. bw BPA + HFD + Suc; D: 40 mg/kg. bw BPA + 40 mg/kg. bw
CdCl2 + HFD + Suc; and E: HFD + Suc orally for 56 days. Finally, brains were excised from each
group and the medial prefrontal cortex was dissected from both hemispheres with right hemisphere
samples processed for hematoxylin and eosin histology and left hemisphere samples homogenized
for biochemical evaluation of oxidative stress markers. One‑way analysis of variance and Tukey’s
post hoc test were used for data analysis with P < 0.05 considered statistically significant.
Results: From our findings, prefrontal glutathione levels were significantly lower (P < 0.05) in the
insulin‑resistant rats (Cd + BPA + HFD + Suc: 120.9 ± 21.89, HFD + Suc: 93.27 ± 17.29) compared
with control rats (244.0 ± 11.57), while prefrontal glutathione reductase activity was significantly
elevated (Cd + BPA + HFD + Suc: 41.02 ± 5.5, HFD + Suc: 41.09 ± 1.68, P < 0.05) compared
to the control rats (20.17 ± 3.27). Prefrontal neurons showed nuclear condensation, cytoplasmic
vacuolations, and clumping of cells. Conclusion: Morphological and biochemical evidence from
the present study suggests that environmental and metabolic factors do combine to induce profound
adverse effects on prefrontal microanatomy and antioxidant system.


Review Article

Turkish Title : Neuroesthetics and its Excitatory Sensitization of the Cerebral Cortex

Torlak Esra
JNBS, 2023, 10(3), p:82-85

DOI : 10.4103/jnbs.jnbs_13_23

The human mind receives, perceives, and processes visual and auditory input daily from the everyday
world of art and culture as an esthetic neural experience involving several regions of the cerebrum.
It is important to comprehend how this process of neuroesthetics works and how it affects each
individual’s emotions and behavior. This article will incorporate various clinical scanning techniques
and methods to examine the anatomical cerebral structures where the effects of external neuroesthetic
stimuli can be correlated with its resultant neural cognitive response. The effects of neuroesthetic
stimuli on the clinical improvement in patients experiencing depression, cognitive decline, and
other forms of behavioral manifestations will be reviewed. The results of these studies (including
international examples, along with various comparative analyses) demonstrate the beneficial effects
of art on the pleasure centers of the brain and its consequent positive effects on patients’ behavior and
emotions, thus exemplifying the short‑ and long‑term importance of incorporation of neuroesthetics
in not only the clinical setting but also in our global society.


Review Article

Turkish Title : Impact of Nutrition on Depression: A Review of Some Dietary Components with Antidepressant Effects and Their Mechanism of Action

Ekpo Ubong Udeme,Umana Uduak Emmanuel,Sadeeq Abubakar Adamu
JNBS, 2023, 10(3), p:86-96

DOI : 10.4103/jnbs.jnbs_5_23

Recent years have seen a surge in psychiatric diseases, which has resulted in considerable disease
distress and considerably decreased living conditions. Many considerable synthetic medications have
been used to treat these illnesses throughout the years, but they have been found to have limited
effects and substantial recurrence risks in many individuals. Mental illnesses such as depression
and anxiety are persistently on the rise around the world, posing serious challenges to the affected
person’s and their family members’ personal lives. There is mounting evidence that suggests the gut–
brain axis (GBA) contributes to the genesis and development of psychiatric diseases. This review
focuses on contemporary dietary therapies such as Mediterranean diets and dietary supplements
and emphasizes nutrition’s critical role in psychiatric care through the GBA. Several research have
indicated that dietary quality affects mental health because it controls metabolic processes, has
anti‑inflammatory and antiapoptotic characteristics, and promotes neurogenesis and synaptogenesis.
This study demonstrates many dietary components, their relationships to depression, and how they
work. The use of dietary recommendations to support mental health appears to be a novel, affordable,
useful, nonpharmacological intervention for people with mental problems.


ISSN (Print) 2149-1909
ISSN (Online) 2148-4325

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