Background: Epilepsy is a neurological illness that disturbs the central nervous system and is
characterized by regular convulsions. Over 70 million people worldwide are thought to have
epilepsy, with the prevalence rate estimated to be around 1%. Aims: The objective of this study
was to assess antiepileptic activities and histological changes after Mentat administration in the
hippocampus of pentylenetetrazole (PTZ)‑induced seizure mice. Materials and Methods: Twenty
Swiss albino mice (18–28 g) were divided into four groups (n = 5) and were given the following
intraperitoneally, 2 ml/kg distilled water and 50 mg/kg PTZ to Groups 1 and 2 animals, respectively.
Groups 3 and 4 animals were given 200 mg/kg and 400 mg/kg of Mentat, respectively, 1 h before
the administration of PTZ and were observed for 300 s. After the experiment, all surviving animals
in the various groups were humanely sacrificed and the brains were harvested and preserved in
10% buffered formalin. The brain tissues were processed using routine histological procedures
and stained with hematoxylin and eosin. Results: Results of this revealed that Mentat was able to
delay the onset time of seizure and offered quantal protection to the animals. Mentat also showed
a dose‑dependent ameliorative effect against histological changes following PTZ administration in
mice. Conclusion: Mentat attenuates PTZ‑induced seizure in mice.