JNBS
Üsküdar Üniversitesi

Original Article

DISTRIBUTION OF DOPAMINE RECEPTOR 2 (DRD2) RS1800497 POLYMORPHISMS IN PROFESSIONAL CYCLIST

Turkish Title : DISTRIBUTION OF DOPAMINE RECEPTOR 2 (DRD2) RS1800497 POLYMORPHISMS IN PROFESSIONAL CYCLIST

Karagöz Esra,Şılar Çisem,Yılmaz Özlem Özge,Polat Tolga,Aslan Beste Tacal,Baltacıoğlu Begüm Su,Dogan Canan Sercan,Kaman Tugba,Ulucan Korkut
JNBS, 2020, 7(3), p:166-169

DOI : 10.4103/jnbs.jnbs_34_20

Genetic and environmental factors are important determinants of the athletic performance. Sports genetic determines certain the alleles for the identification of the genes that affect athletic performance. Comprehensive researches, including the biology of mental properties are accumulating due to the improvement of the information of molecular biology. Dopamine is an important neurotransmitter of the dopaminergic system that affects the athlete mentally and psychologically. In this study, our goal is to determine the genotype and allele distributions of the DRD2 rs180047 polymorphism in the cyclists. 19 cyclists and 52 sedentary individuals (controls) participated in our study. Genotyping was carried out by real time PCR (rt-PCR) after DNA was isolated from buccal epithelial cells. In our cohort, AG and GG genotypes were detected as 6 (32%) and 13 (68%), respectively. In the control group, the respective AA, AG and GG genotypes were detected as 9 (17%), 18 (35%) and 25 (48%). No statistically significant difference was detected in terms of genotype distribution between the two groups (p= 0,1107). When allelic distributions were examined, in athlete cohort. A and G allele numbers were counted as 6 (16%) and 32 (84%), respectively. In the control group, same alleles were count as 36 (35%) and 68 (65%). There was no significant difference in the terms of alleles in our study cohort (p=0,0295). In our cohort, GG genotype and the G allele of the DRD2 rs1800497 polymorphism were dominant. Recent studies showed the association of the A allele with addiction. Therefore we hypothesized the association of the related allele and sucess in cyclists. Although we were unable to find statistically significant difference, we suggest to analyse the same polymorphism in athletes with different sport branches to fulfill the role of the given polymorphism.

Genetic and environmental factors are important determinants of the athletic performance. Sports genetic determines certain the alleles for the identification of the genes that affect athletic performance. Comprehensive researches, including the biology of mental properties are accumulating due to the improvement of the information of molecular biology. Dopamine is an important neurotransmitter of the dopaminergic system that affects the athlete mentally and psychologically. In this study, our goal is to determine the genotype and allele distributions of the DRD2 rs180047 polymorphism in the cyclists. 19 cyclists and 52 sedentary individuals (controls) participated in our study. Genotyping was carried out by real time PCR (rt-PCR) after DNA was isolated from buccal epithelial cells. In our cohort, AG and GG genotypes were detected as 6 (32%) and 13 (68%), respectively. In the control group, the respective AA, AG and GG genotypes were detected as 9 (17%), 18 (35%) and 25 (48%). No statistically significant difference was detected in terms of genotype distribution between the two groups (p= 0,1107). When allelic distributions were examined, in athlete cohort. A and G allele numbers were counted as 6 (16%) and 32 (84%), respectively. In the control group, same alleles were count as 36 (35%) and 68 (65%). There was no significant difference in the terms of alleles in our study cohort (p=0,0295). In our cohort, GG genotype and the G allele of the DRD2 rs1800497 polymorphism were dominant. Recent studies showed the association of the A allele with addiction. Therefore we hypothesized the association of the related allele and sucess in cyclists. Although we were unable to find statistically significant difference, we suggest to analyse the same polymorphism in athletes with different sport branches to fulfill the role of the given polymorphism.


Original Article

VITAMIN B12 AND FOLIC ACID IN DEPRESSION AND ANXIETY: A PILOT STUDY

Turkish Title : VITAMIN B12 AND FOLIC ACID IN DEPRESSION AND ANXIETY: A PILOT STUDY

Erensoy Habib
JNBS, 2020, 7(3), p:160-165

DOI : 10.4103/jnbs.jnbs_32_20

The association between nutrition and mental diseases has been extensively studied. Vitamin B12 and folic acid are the main vitamins in the development of the central nervous system. This study aimed to investigate the relationship between vitamin B12 and folic acid levels with depression and anxiety. A total of 150 patients (77 with anxiety and 73 with depression) between 18 and 79 were enrolled. The initial mood state was evaluated using Beck’s Depression Inventory-II (BDI-II) and Beck’s Anxiety Inventory (BAI) for the presence of depression and anxiety, respectively. Venous blood samples were collected after overnight fasting and vitamin B12 and folic acid levels were measured. Serum concentrations of folic acid were significantly lower in patients with depression than those with anxiety (p=0.04). Substantially higher vitamin B12 levels were described in men than females counterparts with severe depression (p=0.049). Additionally, there was a significant inverse correlation between folic acid levels and Beck’s inventory score among patients with severe depression (r=-0.250, p=0.049). Serum levels of vitamin B12 and folic acid could be used as markers that assess anxiety and depression’s therapeutic efficiency.

The association between nutrition and mental diseases has been extensively studied. Vitamin B12 and folic acid are the main vitamins in the development of the central nervous system. This study aimed to investigate the relationship between vitamin B12 and folic acid levels with depression and anxiety. A total of 150 patients (77 with anxiety and 73 with depression) between 18 and 79 were enrolled. The initial mood state was evaluated using Beck’s Depression Inventory-II (BDI-II) and Beck’s Anxiety Inventory (BAI) for the presence of depression and anxiety, respectively. Venous blood samples were collected after overnight fasting and vitamin B12 and folic acid levels were measured. Serum concentrations of folic acid were significantly lower in patients with depression than those with anxiety (p=0.04). Substantially higher vitamin B12 levels were described in men than females counterparts with severe depression (p=0.049). Additionally, there was a significant inverse correlation between folic acid levels and Beck’s inventory score among patients with severe depression (r=-0.250, p=0.049). Serum levels of vitamin B12 and folic acid could be used as markers that assess anxiety and depression’s therapeutic efficiency.


Original Article

THE DEVELOPMENT OF A FUZZY LOGIC MODEL-BASED SUICIDE RISK ASSESSMENT TOOL

Turkish Title : THE DEVELOPMENT OF A FUZZY LOGIC MODEL-BASED SUICIDE RISK ASSESSMENT TOOL

Ayhan Fatma,Üstün Besti,Ergüzel Türker Tekin
JNBS, 2020, 7(3), p:152-159

DOI : 10.4103/jnbs.jnbs_30_20

The purpose of the research was to develop a fuzzy logic model-based risk assessment tool and to determine the views of health professionals working in community mental health centers concerning this. A methodological method was employed in developing the fuzzy logic model-based risk assessment tool, and the qualitative research method was used to elicit attitudes toward it. In the first stage, the suicide risk assessment tool was developed. In second stage the health professionals used the suicide risk assessment tool for four weeks. Feedback regarding health professionals’ opinions of the suicide risk assessment tool was then elicited handling a semi-structured reportage form, and data were investigate handling descriptive analysis. Health professionals reported powerful aspects making the suicide risk assessment tool a functional, practical, comprehensive, and highly applicable guideline. Participants also recommended the addition to the results screen of a chart showing the course of the suicide risk assessment, and that the reliability and validity of the tool be confirmed. In conclusion, health professionals expressed positive opinions regarding the scope of the suicide risk assessment tool and its measurement of that risk. Following confirmation of its reliability and validity, it may be useful for the fuzzy logic-based suicide risk assessment form to be integrated into and applied in the community health centers system.

The purpose of the research was to develop a fuzzy logic model-based risk assessment tool and to determine the views of health professionals working in community mental health centers concerning this. A methodological method was employed in developing the fuzzy logic model-based risk assessment tool, and the qualitative research method was used to elicit attitudes toward it. In the first stage, the suicide risk assessment tool was developed. In second stage the health professionals used the suicide risk assessment tool for four weeks. Feedback regarding health professionals’ opinions of the suicide risk assessment tool was then elicited handling a semi-structured reportage form, and data were investigate handling descriptive analysis. Health professionals reported powerful aspects making the suicide risk assessment tool a functional, practical, comprehensive, and highly applicable guideline. Participants also recommended the addition to the results screen of a chart showing the course of the suicide risk assessment, and that the reliability and validity of the tool be confirmed. In conclusion, health professionals expressed positive opinions regarding the scope of the suicide risk assessment tool and its measurement of that risk. Following confirmation of its reliability and validity, it may be useful for the fuzzy logic-based suicide risk assessment form to be integrated into and applied in the community health centers system.


Original Article

THE DISTRIBUTION OF BRAIN-DERIVED NEUROTROPHIC FACTOR (BDNF) RS6265 POLYMORPHISM IN TURKISH VOLLEYBALL PLAYERS

Turkish Title : THE DISTRIBUTION OF BRAIN-DERIVED NEUROTROPHIC FACTOR (BDNF) RS6265 POLYMORPHISM IN TURKISH VOLLEYBALL PLAYERS

Polat Tolga,Doğan Canan Sercan,Eken Başak Funda,Yılmaz Özlem Özge,Şılar Çisem,Karapınar Gözdem,Baltacıoğlu Begümsu,Ekmekçi Rıdvan,Ulucan Korkut
JNBS, 2020, 7(3), p:147-151

DOI : 10.4103/jnbs.jnbs_28_20

Athletic performance is associated with many environmental factors such as inborn genetic factors, nutrition, psychological factors, and education. We aimed to analyze the brain derived neurotrophic factor (BDNF) rs6265 polymorphism, which is an important genetic marker related to psychological factors, in 21 professional female volleyball players and compare it with the control group. Genotyping was assessed by Real-time PCR technique. BDNF rs6265 polymorphism genotypes were calculated as 72% and 28% for GG and GA in volleyball players, respectively. No AA genotype was detected. In the control group, the GG, GA and AA genotype percentages were calculated as 57.8, 36.3 and 5.9, respectively. In the allelic distribution, the percentages in the athlete group were calculated as 86% (36) for the G allele and 14% (6) for the A allele, respectively. In the control group, for the G and A alleles, respectively; it was 76.25% and 23.75%. No statistical significance was found in terms of both genotype distribution (p = 0.407) and allelic frequency distribution (p = 0.218). Our results were in line with data indicating the stress and anxiety-related nature of professional volleyball players. More studies with more athletes and more groups of athletes are needed to understand the effect of these parameters on volleyball players.

Athletic performance is associated with many environmental factors such as inborn genetic factors, nutrition, psychological factors, and education. We aimed to analyze the brain derived neurotrophic factor (BDNF) rs6265 polymorphism, which is an important genetic marker related to psychological factors, in 21 professional female volleyball players and compare it with the control group. Genotyping was assessed by Real-time PCR technique. BDNF rs6265 polymorphism genotypes were calculated as 72% and 28% for GG and GA in volleyball players, respectively. No AA genotype was detected. In the control group, the GG, GA and AA genotype percentages were calculated as 57.8, 36.3 and 5.9, respectively. In the allelic distribution, the percentages in the athlete group were calculated as 86% (36) for the G allele and 14% (6) for the A allele, respectively. In the control group, for the G and A alleles, respectively; it was 76.25% and 23.75%. No statistical significance was found in terms of both genotype distribution (p = 0.407) and allelic frequency distribution (p = 0.218). Our results were in line with data indicating the stress and anxiety-related nature of professional volleyball players. More studies with more athletes and more groups of athletes are needed to understand the effect of these parameters on volleyball players.


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ISSN (Print) 2149-1909
ISSN (Online) 2148-4325

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